Platelets mediate inflammatory monocyte activation by SARS-CoV-2 spike protein

Platelets mediate inflammatory monocyte activation by SARS-CoV-2 spike protein

Blog Article

Infection with SARS-CoV-2, the causative agent of COVID-19, causes mild to moderate disease in most patients but carries a risk of morbidity and mortality.Seriously affected individuals manifest disorders of hemostasis Grille Inserts and a cytokine storm, but it is not understood how these manifestations of severe COVID-19 are linked.Here, we showed that the SARS-CoV-2 spike protein engaged the CD42b receptor to activate platelets via 2 distinct signaling pathways and promoted platelet-monocyte communication through the engagement of P selectin/PGSL-1 and CD40L/CD40, which led to proinflammatory cytokine production by monocytes.These results explain why hypercoagulation, monocyte activation, and a cytokine storm are correlated in patients severely affected Table Place Name by COVID-19 and suggest a potential target for therapeutic intervention.